Product Information
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Protein full name |
Apoptosis-associated speck-like protein containing a CARD |
|
Synonyms |
ASC, CARD5, hASC, PYCARD, PYD and CARD domain containing, TMS, TMS 1, TMS1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Human TMS1/ASC |
|
Uniprot ID |
Q9ULZ3 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm,Inflammasome, Endoplasmic reticulum, Mitochondrion, Nucleus |
|
Predicted MW. / Observed MW. |
22 kDa / 22-25 kDa |
Applications
|
WB |
Human |
1: 300-1: 600 |
THP-1, MCF7 |
|
IHC/IF |
Human |
1 :400-1: 800 |
tonsil, liver, colon |
Background
PYCARD , also known as ASC or TMS1, is a 195 amino acid protein containing an N-terminal Pyrin-like domain (PYD) and an 87 residue C-terminal Caspase-associated recruitment domain (CARD). It promotes caspase-mediated apoptosis which is mediated predominantly through the activation of caspase-9.
Images
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Western blot analysis of ASC (GB115270) at dilution of 1: 300 |
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Immunohistochemistry analysis of paraffin embedded human tonsil using ASC (GB115270) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded human tonsil using ASC (GB115270) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded human liver using ASC (GB115270) at dilution of 1: 1800 |
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Immunohistochemistry analysis of paraffin embedded human colon using ASC (GB115270) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded human liver using ASC (GB115270) at dilution of 1: 600 |
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Immunohistochemistry analysis of paraffin embedded human colon using ASC (GB115270) at dilution of 1: 600 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
